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Parkinsons Disease - Stem Cell Treatment

Parkinson's disease (PD) is a neurodegenerative issue that predominately influences dopamine-delivering ("dopaminergic") neurons in a particular territory of the brain called substantia nigra.

What Causes Parkinson’s Disease?

  • Genetic Mutation There are some genes which, when they start mutating, may cause Parkinson's infection. In any case, these mutated genes are extremely uncommon, except in situations where Parkinson's keeps running in the family. There are additionally some gene variations which appear to increase the risk of Parkinson's disease marginally.
  • Environmental Factors Doctors think there are some natural components and toxins which trigger Parkinson's disease, even though they feel the risk is little.
  • Presence of Lewy bodies in the Brain Changes occurring inside the brain may likewise be a trigger for Parkinson's disease. Lewy bodies are proteins found in brain cells which are biomarkers of the disease and may hold the key to discovering the exact reason.
    • Alpha-synuclein in Lewy bodies There are a wide range of substances found in Lewy bodies, yet researchers are concentrating on alpha-synuclein proteins. Alpha-synuclein proteins don't separate; they form clumps in the cells which are suspected of adding to the Parkinson's disease.

Who Qualifies for Parkinson’s Stem Cell Treatment?

If a person is suffering from following symptoms, the doctor often recommends diagnostic tests. If a patient’s checklist consists of a majority of these symptoms, stem cell treatment is selected. Moreover, if the stem cell treatment is the last resort, doctors consider a person eligible for regenerative treatment.

  • Tremor A tremor, or shaking, starts in a limb, often in a hand or fingers. The patient may a rub their thumb and index finger forward and backwards, known as a pill-rolling tremor. The hand experiences tremor despite being still.
  • Hindered development (bradykinesia) After some time, Parkinson's disease may slow-down your development, making simple tasks troublesome and tedious.
  • Unbending Muscles Muscle rigidness may happen in any part of the body. The hardened muscles can be painful and confine the patient's range of movement.
  • Impeded Posture and Balance The patient may stoop while walking. It will be hard to maintain balance because of Parkinson's disease.
  • Loss of Automatic Movements The patient's capacity to perform the unconscious movement, including flickering, smiling or swinging the arms while walking.
  • Speech Changes The patient may talk delicately, rapidly, slur or falter before speaking.
  • Writing Changes A simple task like writing suffers because of the hand tremors.

How are the Stem Cells Obtained?

The initial stage in a stem cell treatment begins with the collection of nascent cells from the patient's body. These cells are generally obtained from the circulatory system (peripheral blood stem cells). An initiation procedure brings the stem cells from the bone marrow into the peripheral circulatory system. Once the undeveloped cells are in the circulation system, the gathering procedure begins.

The blood is segregated using an apheresis machine. This technique takes two or three hours and is repeated until the point when the necessary amount of stem cells are accumulated. Once the stem cells are gathered, they are solidified in a research centre until required.

The specialist uses chemotherapy and radiation to destroy the unhealthy cells before arranging the stem cell transplant or therapy. The transplant happens two days after the radiation treatment is done.

The solidified sacs of stem cells are defrosted to set them up for the transplant. Once defrosted, the stem cells are reintroduced into the circulatory framework (like blood transfusion). This procedure takes around an hour. The stem cells venture out where they travel to the bone marrow and make new cells to cure Parkinson's disease. This strategy is called engraftment.

How are Stem Cells Administered?

At first, the stem cells are extracted, processed and enriched, so that they can be reintroduced into the patient's body. Doctors use two methods which are used to infuse the stem cells in the patient’s body.

  • Intrathecal Administration Through this mode, stem cells are diffused in the cerebrospinal liquid through the subarachnoid spaces of the spinal canal.
  • Intravenous Administration Through this mode, cells are imbued through the veins alongside the mannitol to grow blood volumes in the body.

Prognosis

In a remarkable leap forward for the treatment of Parkinson's disease, analysts working with guinea pigs indicate it is possible to make dopamine cells from undeveloped embryonic cells and transplant them into the brain, thus supplanting the cells lost to the ailment.

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Hospitals

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Indraprastha Apollo

Apollo Hospitals is widely recognized as the pioneer of private healthcare in India, and was the country`s first corporate hospital. The Apollo Hospitals Group,

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Fortis Hospital

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Metro Hospital

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BLK Hospital

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Action Cancer Hospital

Action Cancer Hospital, founded by Lala Mange Ram Aggarwal, is the first state-of-the-art cancer care hospital in the heart of West Delhi.

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Denvax Clinics

DENVAX is dendritic cell based cancer immunotherapy.

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Artemis Hospital

Sector 51, Gurgaon 122001 Haryana, India

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Fortis Escorts Heart Institute

Okhla Road, New Delhi - 110 025 (INDIA)

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Max Superspeciality Hospital Saket

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Columbia Asia

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Fortis Memorial Research Institute, Gurgaon

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Medanata The Medicity

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Paras Hospitals Gurgaon

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Dharamshila Narayana Superspeciality Hospital

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Narayana Multispeciality Hospital

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Fortis Malar Hospital

Fortis Malar Hospital 52, First Main Road, Gandhi Nagar, Adyar Adyar Chennai 600 020

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Manipal Hospitals

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Apollo Hospital

No. 21, Greams Lane 320, Off. Greams Road, Chennai - 600006

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Gleaneagle Global Health city

439, Cheran Nagar, Perumbakkam, Chennai, Tamil Nadu 600100

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Seven Hills Hospital

Marol Maroshi Road, Shivaji Nagar JJC, Marol, Andheri East, Mumbai, Maharashtra 400059

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Wock Hardt Hospital

Wockhardt Towers BandraKurla Complex, Bandra (East) Mumbai 400051 Maharashtra, India

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Max Super Speciality Hospital Shalimar Bagh

C and D Block, Shalimar Place Site, Shalimar Bagh, New Delhi, Delhi 110088

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Doctors

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Dr. Aloy J MukherjeeBariatric Surgery, General & Advanced Laparoscopic Surgery

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Dr. Partha Prateem ChoudhuryInterventional Cardiology

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Dr. Vinit SuriNeurology

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Dr. Shuvendu Prosad RoyMBBS, MS-Orthopaedic Surgery

Orthopedics Surgery. Hospital - Fortis Hospital, Vasant Kunj, Delhi

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Dr. Gurinder BediMS, DNB, FRCS, FRCS-ortho

Orthopedics Surgery. Hospital - Fortis Hospital, Vasant Kunj, Delhi

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Dr. Jamal A. KhanMBBS MD

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Medical Oncology & Haematology. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Monica BambrooHOD : Dermatology & Cosmetology

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Dr. Nidhi RawalPaediatric Cardiology

Cardiology. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Manjinder SandhuPaediatric Cardiology

Cardiology. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. SK RajanHead of Spine Surgery & Associate Director, Neurosurgery

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Dr. Anish GuptaHead & Neck Surgeon

ENT. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Anjana SatyajitDentistry

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Dr. Arpit JainSenior Consultant

Internal Fixation of Fractures Surgery. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Ashu Kumar JainSr. Consultant

Anaesthesia & Pain Medicine. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Ashutosh ShuklaSr. Consultant

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Dr. B.K. SinghSenior Surgeon

Orthopedics Surgery. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Dheeraj KapoorSr. Consultant

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Dr. Hitesh GargConsultant Spine Surgeon, Artemis Health Institute, Gurgaon, Haryana

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Dr. I P S OberoiOrthopaedics

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Dr. Ila GuptaReproductive Medicine

Obesity. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Kaushal MadanDigestive and Liver Diseases

Gastroenterology. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Lakshmi Kant TripathiNephrology & Kidney Transplant

Nephrology. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Paritosh S GuptaGeneral & MI Surgery

General & MI Surgery. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Rajesh K. VermaOrthopaedics

Orthopedics Surgery. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Ramdip RayLiver Transplant & GI Surgery

Organ Transplant. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Aditya GuptaAdditional Director – Neurosurgery

Neurological Surgery. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Renu Raina SehgalSenior Consultant

Obesity. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Subodh Chandra PandeDirector - Radiation Oncology and Co-Director - Cyberknife Centre

Oncology. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Akhil GovilCardio Thoracic and Vascular Surgery

Cardiology. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Himanshu GargHead

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Dr. Geeta Baruah Nath Sr. Consultant

Obstetrics & Gynaecology. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. S. V. KotwalMS General Surgery

Urology. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Indu Bansal AgarwalSenior Consultant - Radiation Oncology

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Dr. Sameer KaushalSr. Consultant

Organ Transplant. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Nitin Goel GoelConsultant

Paediatric Surgery. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Sanjay SarupPaediatric Orthopaedics & Spine surgery

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Dr. Shalabh AgrawalUrologist

Urology. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Rajiv ChhabraSr. Consultant

Paediatric Surgery. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Sonu Balhara AhlawatSenior Consultant

Reproductive Medicine. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. T K ThusooSenior Surgeon

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Dr. Shashidhar TBHead and Neck surgeon

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Dr. Vikram Barua KaushikAssociate Urologist

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Dr. Sumit SinghDirector

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Dr. Viresh MahajanDirector - Pediatric Cardiology

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Dr. Sumeet AgarwalHead

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Dr. Noaline SinhaSr. Consultant

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Dr. Durgatosh PandeyDirector & Senior Consultant

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Dr. Biswajyoti HazarikaDirector- Surgical Oncology (Head & Neck)

Oncology. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Subhash Jangid Senior Consultant

Orthopedics Surgery. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Veena Bhat Obstetrics & Gynaecology

Obesity. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Vipul Nanda Consultant - Cosmetic & Plastic Surgery

Plastic & Reconstructive Surgery. Hospital - Artemis Hospital, Gurugram Haryana

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Dr. Rohit MehtaHead of Department, Physiotherapy & Rehabilitation

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Dr. Inder Mohan ChughAssociate Director & HOD - Interventional Pulmonology & Sleep Medicine

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Dr. Manoj KhanalSenior Consultant Neurology

Back and Neck Pain. Hospital - Max Super Speciality Hospital Shalimar Bagh, New Delhi

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Dr. Vineeta GoelAssociate Director, Radiation Oncology

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Dr. Mannu BhatiaConsultant - Orthopaedics & Joint Replacement

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Dr. Naresh Kumar GoyalAssociate Director & HOD - Cardiology(Clinical & Research)

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Dr. Naveen BhamriHead of Department & Associate Director Interventional Cardiology

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Dr. Monisha GuptaConsultant - Gynae Oncology

Oncology. Hospital - Max Super Speciality Hospital Shalimar Bagh, New Delhi

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Dr. Vineet Govinda GuptaAssociate Consultant - Oncology

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Dr. Harsh WardhanSenior Consultant - Paediatric Surgery

Paediatric Surgery. Hospital - Max Super Speciality Hospital Shalimar Bagh, New Delhi

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Dr. Yogesh ChhabraConsultant - Nephrology & Renal Transplantation

Kidney Transplant. Hospital - Max Super Speciality Hospital Shalimar Bagh, New Delhi

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Dr. Raju EaswaranSenior Consultant - Orthopaedics & Sports Injury

Orthopedics Surgery. Hospital - Max Super Speciality Hospital Shalimar Bagh, New Delhi

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Dr. Archit PanditConsultant - Surgical Oncology

Oncology. Hospital - Max Super Speciality Hospital Shalimar Bagh, New Delhi

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Dr. Rakesh K. DuaDirector & Head - Neurosurgery(Spine & Brain)

Neurological Surgery. Hospital - Max Super Speciality Hospital Shalimar Bagh, New Delhi

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Dr. Nikhil AgnihotriSenior Consultant

Minimally Invasive Spine Surgery. Hospital - Max Super Speciality Hospital Shalimar Bagh, New Delhi

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Dr. Anil Kumar VarshneyDirector & HOD - Urology

Urology. Hospital - Max Super Speciality Hospital Shalimar Bagh, New Delhi

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Dr.(Col.) Ranga Rao RangarajuDirector - Medical Oncology

Oncology. Hospital - Max Super Speciality Hospital Shalimar Bagh, New Delhi

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Dr. Rudra Prasad AcharyaMS(General surgery), Fellow(Surgical Oncology ft Colorectal Surgery), Sr. Consultant ft Head

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Dr. Gaurav DixitConsultant - Medical Oncology, Haematology and Bone Marrow Transplant

Bone Marrow. Hospital - Max Super Speciality Hospital Shalimar Bagh, New Delhi

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