Autologous stem cell transplantation (ASCT) assumes a vital part in the treatment of patients with Hodgkin's lymphoma. Most patients with Hodgkin's lymphoma are recuperated with combination chemotherapy, which might be coupled with radiation treatment. ASCT is presently an ideal treatment for those patients who could not benefit from chemotherapy and radiation treatment.
Hodgkin’s disease (or Hodgkin's lymphoma) is cancer of the lymphatic system. This condition drastically weakens your immune system by destroying lymphatic cells which provide natural resistance to infections and diseases.
In autologous stem cell transplant, the stem cells gathered from the patient's body collected, frozen and put away until required. An autologous stem cell is offered to the patients who are undergoing chemotherapy and radiation therapy. The stem cells are intravenously transplanted into the patient's body to regenerate healthy lymphatic cells.
The initial phase in an autologous stem cell transplant starts with harvesting the stem cells. These cells are ordinarily acquired from the bloodstream (peripheral blood stem cells). An activation process brings the stem cells from the bone marrow into the peripheral circulation system. Once the stem cells are in bloodstream, the collection process starts.
The blood is isolated utilising an apheresis machine. This procedure takes a couple of hours and is repeated until the required amount of stem cells are gathered. Once the stem cells are collected, they are frozen in a laboratory until needed.
The specialist uses chemotherapy and radiation to obliterate the diseased cells before planning the stem cell transplant. The transplant happens two days after the radiation therapy is finished.
The frozen sacks of undeveloped cells are defrosted to prepare them for the transplant. Once defrosted, the stem cells are re-introduced into the circulatory system (like blood transfusion). This procedure takes around 60 minutes. The stem cells travel deep down to the bone marrow and create new stem cells. This procedure is called engraftment. ASCT has shown some promising results in treating Hodgkin's lymphoma.
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